Bioactive compounds, antimicrobial, antioxidant and protein-‎aggregation inhibition of Lavandula angustifolia and Matricaria chamomilla

Document Type : Research Paper

Authors

Department of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran

Abstract

Lavandula angustifolia and Matricaria chamomilla are two important natural and medicinal sources used in Iranian pharmaceutical industries. Anti–Alzheimer's effects of these medicinal plants were studied by inhibitory properties for the amyloid production. Antibacterial effects on standard strains of Staphylococcus aureus (ATCC1330) and Escherichia coli (ATCC1122) were determined by instruction for minimum inhibitory, minimum bactericidal and agar well diffusion methods. Ultraviolet–visible spectroscopy was used to study amyloid production. GC-MS results showed the most important compounds were Eucalyptol, Camphor, and Borneol in the case of L. angustifolia and Benzo[h]quinoline and Pentalane in the case of M. chamomile. The minimum inhibitory concentration (MIC) values for L. angustifolia extract were 58 mg/ml in the case of both bacteria and for M. chamomile extract were 59 and 118 mg/ml for S. aureus and E. coli. The minimum bactericidal concentration (MBC) values of L. angustifolia extract were 116 and 232 mg/ml in the case of S. aureus and E. coli, also for M. chamomile extract were 237 mg/ml for both bacteria. In the agar diffusion method, both extracts had an inhibitory effect on S. aureus, and just M. chamomile had an inhibitory effect on E. coli. Moreover, the most protein-‎aggregation inhibition of the extracts was determined 12% and 20% for L. angustifolia of M. chamomile extract, respectively. Overally, both of the extracts showed the potential antimicrobial and anti–amyloidogenic properties which need to more study.

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References

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Microbiology, Metabolites and Biotechnology
Volume 7, Issue 1
June 2024
Pages 57-66

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